Cluttered house here! I moved into DH's tiny two-bedroom which was full on stuff (he lived here 10 years before I came along) almost five years ago and have spent the past five years decluttering. The end is far from sight, but there is a glimmer of light FINALLY! I did the FlyLady thing and it really helped a lot. I have some routines down. Okay, maybe one. I have less guilt about it all, too. I don't obsessively clean, but once a week I try to vacuum and clean the bathrooms/kitchen sinks. I load up the dishwasher as I clear up from breakfast/lunch/dinner and try to unload it every morning.
Clothes are something else. Right now it's getting out of control again because I haven't washed in a few days (really bad sick kids to contend with). But, to get your dirty clothes under control, just do one load a day. Fold it/hang it as it comes out of the dryer and put it right away. Just one load a day (two if you can manage it). Soon enough, the pile will get smaller.
And if you plan on tacling your dining room table, set your timer for 15 minutes and work on it for that long. Just a little every day helps. I also toss the junk mail as soon as it comes in the house. Catalogs, too, especially when things get out of control. Used to keep it all, but not any more!
I'm lucky because my boys, both of them, are fine to play by themselves for awhile. Baby not as much alone time, but I find he needs his time, too. And it's neat to see how he plays without me--those little brains are amazing!!! So long as he doesn't catch a glimpse of me, he's good to go.
I also barter with my sister to watch the kids if things get especially messy. And have a college-aged friend come over to babysit while I clean up, purge, sort, whatever.
Kristin